Neurobiological Correlates of Psilocybin Response in Depression.
The primary care companion for CNS disorders May 23, 2023 Saleha Qasim, Zaofashan Zaheer, Muhammad Youshay Jawad et al. 2 citations
A systematic review of five neuroimaging studies found that psilocybin therapy transiently increases global connectivity in major neural tracts and activates specific brain areas, and these changes are associated with antidepressant response in depressed patients. The pattern of functional brain changes resembles a 'brain reset' phenomenon and may serve as a predictor of psilocybin's antidepressant effects. Four of the studies were open-label, and one combined an open-label design with a randomized controlled trial. Three studies included psilocybin-assisted psychotherapy, and participants in most studies had treatment-resistant depression.