Psychoactive plant derivatives (ayahuasca, ibogaine, kratom) and their application in opioid withdrawal and use disorder - a narrative review.
Journal of addictive diseases January 1, 2024 Alexandra Arenson, Cynthia I Campbell, Ilan Remler 8 citations
People with opioid use disorder and withdrawal are increasingly using plant-based substances like ayahuasca, ibogaine, and kratom to self-treat, often due to limited access to standard care. A narrative review of evidence from 2012 to 2022 indicates these substances may help through unique pharmacodynamic effects, ritual practices, and increased neuroplasticity. However, the supporting evidence comes mainly from small observational studies or animal research. High-quality, long-term studies are needed to determine their safety and effectiveness for treating opioid withdrawal and opioid use disorder.