DMT and harmala alkaloids: an exploratory study of oral Acacia based formulations in healthy volunteers.
Front Psychiatry August 15, 2025 Yvonne A. Bonomo, Amanda F. Norman, Lisa Collins et al. 1 citation
Three Acacia-based formulations of DMT and harmala alkaloids were safe and well tolerated in 9 healthy volunteers who had previously used ayahuasca. No serious adverse events occurred, and physical exams, vital signs, and lab tests showed no clinically significant changes. Participants rated the subjective experience of all formulations as generally similar to ayahuasca, and one formulation (ACL-010) was rated as similar or more beneficial. Four-week follow-up measures of psychological wellbeing and perceptual effects showed little difference between formulations. The small sample and open-label design limit generalizability, but the results suggest Acacia-derived DMT formulations are a feasible alternative for future clinical trials.