Effect of the CB1 cannabinoid agonist WIN 55212-2 on the acquisition and reinstatement of MDMA-induced conditioned place preference in mice
Behavioral and Brain Functions March 22, 2010 Carmen Manzanedo, Marta Rodríguez-Arias, Manuel Daza-Losada et al. 36 citations
In mice, a low dose of the cannabinoid agonist WIN 55,212-2 increased the rewarding effects of a low dose of MDMA, while a higher dose of the cannabinoid decreased the preference induced by higher MDMA doses. The CB1 antagonist SR 141716 also increased the rewarding effects of the lowest MDMA dose. Animals given the highest WIN dose plus a non-neurotoxic MDMA dose showed decreases in striatal dopamine and cortical serotonin. WIN-induced conditioned place preference was reinstated by MDMA priming, but WIN did not reinstate MDMA-induced preference. The findings indicate the cannabinoid system influences MDMA's rewarding effects and suggest potential neurotoxic effects when cannabinoids are combined with MDMA.