Efficacy of Nebulized Ketamine versus Ketamine-Clonidine in Reducing Post-Operative Sore Throat: A Randomized Controlled Trial
International Journal of Science and Research (IJSR) September 19, 2025 Deepak Salhan, Hemani Ahuja
A combination of nebulized ketamine and clonidine before general anesthesia reduces the incidence and severity of postoperative sore throat more effectively than ketamine alone or saline. In a randomized trial of 120 patients, sore throat occurred in 12.5% of those receiving the combination at 24 hours after surgery, compared to 47.5% with ketamine alone and 67.5% with saline. The combination also lessened the severity of sore throat. These results indicate that adding clonidine to ketamine nebulization is a valuable option for improving patient comfort after general anesthesia with endotracheal intubation.