Attenuation of the Neuropsychiatric Effects of Ketamine With Lamotrigine
Archives of General Psychiatry March 1, 2000 Amit Anand, Dennis S. Charney, Dan A. Oren et al. 425 citations
A drug that inhibits glutamate release, lamotrigine, reduced several effects of ketamine in healthy adults. Lamotrigine given before ketamine decreased perceptual abnormalities, positive and negative schizophrenia-like symptoms, and learning and memory impairment. However, it increased the immediate mood-elevating effects of ketamine. These findings suggest that glutamate release plays a role in some effects of NMDA receptor blockade and that drugs reducing glutamate release might help treat conditions like schizophrenia, though more research is needed.