Stability of 10-mg/mL and 50-mg/mL ketamine oral solutions.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists April 22, 2021 Dimitri Ancedy, Maria Sebti, Martine Postaire et al. 7 citations
Ketamine oral solutions at 10 mg/mL and 50 mg/mL, prepared in a flavored suspending excipient and stored in amber plastic bottles, remain chemically stable for at least 90 days at both refrigeration (2°C-8°C) and ambient (22°C-25°C) temperatures. Over 90 days, at least 98% of the initial ketamine concentration was retained under all conditions tested. Solution pH, color, and odor also remained unchanged throughout the study period. These results indicate that extemporaneously compounded oral ketamine solutions can be stored for up to 90 days without significant degradation.