Repurposing Ketamine in the Therapy of Depression and Depression-Related Disorders: Recent Advances and Future Potential.
Aging and disease April 29, 2024 Qianting Deng, Emily Parker, Chongyun Wu et al. 8 citations
Depression is a common and long-lasting mental disorder with many interconnected biological pathways. Recent research has found that ketamine, a drug that blocks NMDA receptors, can produce rapid antidepressant effects, offering a new approach to treating mood disorders. This review summarizes current knowledge about signaling pathways and systems involved in depression, drawing from studies of patients and animal models. It focuses on how ketamine works as a fast-acting antidepressant and discusses its potential for preventing or treating stress-related psychiatric conditions.