Modulation of neural complexity and consciousness in temporal lobe seizures: Effects of high-frequency pulvinar stimulation.
Epileptic disorders : international epilepsy journal with videotape June 21, 2025 Ionuț-Flavius Bratu, Nada El Youssef, Stanislas Lagarde et al. 5 citations
Loss of consciousness during temporal lobe seizures is linked to reduced brain signal complexity and abnormal synchronization in the thalamocortical system. The medial pulvinar nucleus (PUM) is involved in seizure spread and awareness impairment. In eight patients with drug-resistant temporal epilepsy, high-frequency PUM stimulation during hippocampus-induced seizures attenuated the decline in neural complexity measured by permutation entropy. Reduced entropy alterations correlated with improved awareness scores on the Consciousness Seizure Scale. The findings suggest that PUM stimulation preserves neural complexity and may help maintain consciousness and cognitive function during seizures, though larger studies are needed.