Novel treatments of depression: bridging the gap in current therapeutic approaches
Exploration of Neuroscience August 5, 2024 Amit Jagtiani 6 citations
Depression treatments that target monoamine neurotransmitters often fail to achieve full remission. This narrative review examines several emerging strategies that go beyond those conventional methods: glutamatergic modulation, brain stimulation techniques, anti-inflammatory agents, interventions on the gut-brain axis, GABA modulation, and psychedelic-assisted therapy. The article describes the mechanisms, clinical efficacy, and safety profiles of these innovative approaches, offering perspectives for improving depression management and addressing current therapeutic gaps.