Defined radio wave frequencies attenuate the head-twitch response in mice elicited by (±)-2,5-dimethoxy-4-iodoamphetamine.
Electromagnetic biology and medicine October 1, 2024 Mary O Vu, B Michael Butters, Clinton E Canal et al. 1 citation
A newly developed electromagnetic signal derived from the serotonin 2 receptor agonist DOI, converted into a playable WAV file, significantly reduced the head-twitch response in mice—a behavioral proxy for psychedelic effects—when administered alongside DOI. The effect was specific: a scrambled version of the signal did not alter the response. The findings suggest that defined electromagnetic signals could potentially modulate the psychoactive effects of serotonergic psychedelics, offering a new strategy to mitigate the heightened anxiety associated with psychedelic therapy. The authors discuss possible mechanisms and connections to prior work showing electromagnetic signals' efficacy in treating pain and cancer.