Urinary Excretion Profiles of 2,5-Dimethoxy-4-alkylthiophenethylamine Analogs in Rats.
Biological & pharmaceutical bulletin January 1, 2016 Tatsuyuki Kanamori, Kenji Kuwayama, Kenji Tsujikawa et al. 1 citation
In rats, the urinary metabolic profiles of three hallucinogenic compounds—2C-T-2, 2C-T-4, and 2C-T-7—differed after oral administration. The major metabolite for 2C-T-7 was a β-hydroxylated-N-acetylated-sulfoxide, while for 2C-T-2 it was the N-acetylated-sulfoxide, and for 2C-T-4 the S-methylated-N-acetylated-sulfoxide predominated. These distinct metabolic patterns suggest that each analog undergoes unique biotransformation pathways.