Synthesis of neoclerodane diterpenes and their pharmacological effects.
Topics in current chemistry January 1, 2011 Kimberly M Lovell, Katherine M Prevatt-Smith, Anthony Lozama et al. 17 citations
Salvinorin A, a unique compound, stands out as the first opioid ligand discovered without a basic nitrogen, challenging traditional understanding. Researchers developed sophisticated synthetic methods to recreate and modify its complex structure, which features seven chiral centers. By focusing on specific structural changes, they successfully created new analogs. These efforts yielded promising compounds with diverse and interesting biological activities, highlighting the power of chemical synthesis in drug discovery.