Novel neoclerodane diterpene derivatives from the smoke of salvinorin A.
Tetrahedron letters September 29, 2010 Zhongze Ma, Gang Deng, David Y W Lee 11 citations
Salvinorin A, a potent and selective kappa opioid receptor agonist, produces intense hallucinogenic effects when smoked. The smoke of salvinorin A contains at least eight neoclerodane diterpene derivatives, which were isolated and identified using spectroscopic methods. The major chemical transformations occurring during smoking include epimerizations, eliminations, and rearrangements, leading to these novel compounds.