Salvinorin A: from natural product to human therapeutics.
Molecular interventions October 1, 2006 Timothy A Vortherms, Bryan L Roth 91 citations
The hallucinogenic plant Salvia divinorum, used traditionally by the Mazatecs for divination and shamanism, has seen increased recreational use in the past decade. Its active component, the neoclerodane diterpene salvinorin A, has been identified as acting through the kappa opioid receptor (KOR) in both in vitro and in vivo studies. This discovery creates opportunities for drug discovery and development targeting a range of psychiatric and non-psychiatric disorders.