Acute ibogaine injection induces expression of the immediate early genes, egr-1 and c-fos, in mouse brain.
Brain research. Molecular brain research December 10, 1999 S F Ali, N Thiriet, J Zwiller 13 citations
A single injection of ibogaine in adult male mice significantly increased the activity of two immediate early genes, egr-1 and c-fos, in several brain regions within 30 minutes. Egr-1 messenger RNA rose in the nucleus accumbens, caudate-putamen, frontal cortex, septum, dentate gyrus, and CA3 region of the hippocampus. C-fos gene expression increased in the caudate-putamen, frontal cortex, dentate gyrus, septum, and CA1 region of the hippocampus. The authors suggest this gene activation may partly stem from ibogaine's stimulant properties, similar to other psychostimulants.