Evidence that ibogaine releases dopamine from the cytoplasmic pool in isolated mouse striatum.
Journal of neural transmission. General section January 1, 1994 L G Harsing, H Sershen, A Lajtha 26 citations
Ibogaine increases the release of dopamine from mouse striatum in a concentration-dependent way, primarily from the cytoplasmic pool rather than from vesicles, and this release is not regulated by presynaptic autoreceptors. The effect is reduced by dopamine uptake inhibitors but not by removing calcium or blocking sodium channels. Ibogaine does not affect dopamine uptake or retention. The dopamine-releasing action may contribute to its hallucinogenic effects observed in African ritual practices.