Two kinds of modification by 5-methoxy-N,N-dimethyltryptamine of contractile responses to electrical stimulation of isolated guinea-pig vas deferens.
Japanese journal of pharmacology April 1, 1987 S Yoshida, T Kuga
The hallucinogen 5-MeODMT has two opposing effects on electrically stimulated contractions of guinea-pig vas deferens. At low concentrations (3×10⁻⁸ to 10⁻⁶ M) it reduces contractions, likely by decreasing neurotransmitter release from sympathetic nerve terminals. At higher concentrations (3×10⁻⁶ to 2×10⁻⁵ M) it potentiates contractions by causing noradrenaline release; this potentiation is blocked by prazosin and ketanserin. 5-MeODMT also reverses the inhibitory effect of clonidine on contractions, an effect inhibited by prazosin and ketanserin. These results indicate that 5-MeODMT modifies sympathetic neurotransmission in a dose-dependent manner.