5-Hydroxytryptamine antagonists and the 5-methoxy-N,N-dimethyltryptamine-induced changes of postdecapitation convulsions.
Pharmacology & toxicology January 1, 1987 T Archer 2 citations
Several compounds that block serotonin (5-HT) receptors were tested for their ability to counteract changes in postdecapitation convulsions (PDCs) caused by 5-MeODMT, a serotonin agonist. Mianserin, methergoline, cinanserin, and methysergide substantially reduced the 5-MeODMT-induced prolongation of the time before convulsions began (latency) and, to a lesser extent, the duration of convulsions. Their effectiveness ranked mianserin > cinanserin > methysergide > methergoline. Pirenperone (a 5-HT2 antagonist) and pimozide (a dopamine antagonist) did not block these effects. When given alone, mianserin, methergoline, cinanserin, and methysergide prolonged convulsion duration but not latency; pirenperone prolonged both; pimozide had no effect. This suggests that 5-MeODMT's effects on PDCs are mediated through 5-HT1 receptors, offering a reliable model for studying spinal function.