Spinal and locus coeruleus noradrenergic lesions abolish the analgesic effects of 5-methoxy-N,N-dimethyltryptamine.
Behavioral and neural biology July 1, 1986 W Danysz, G Jonsson, B G Minor et al. 6 citations
Two experiments on rats show that depleting noradrenaline or serotonin in specific brain and spinal cord regions blocks or reduces pain relief from a drug called 5-MeODMT. Destroying noradrenaline-producing neurons in the locus coeruleus or spinal cord completely eliminated the drug's analgesic effect in three pain tests. Destroying serotonin-producing neurons in the nucleus raphe magnus or spinal cord only partly reduced the effect in two of the tests. The findings indicate that descending noradrenergic and serotonergic pathways interact, likely within the spinal cord, to produce this pain relief.