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Neuroscience research

ISSN 1872-8111

2 papers in the library · 1 citation · publishing 2001-2025

Papers

A systematic study of changes in monoamine neurotransmitters in the rat brain following acute administration of alpha-methyltryptamine (AMT), 5-methoxy-alpha-methyltryptamine (5-MeO-AMT) and 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DiPT).

Neuroscience research July 1, 2025 Kaixi Li, Nan Li, Yuanyuan Chen et al. 1 citation

Three synthetic tryptamines—AMT, 5-MeO-AMT, and 5-MeO-DiPT—alter levels of dopamine and serotonin and their metabolites in specific rat brain regions, including the prefrontal cortex, nucleus accumbens, dorsolateral striatum, and hippocampus. The effects vary by brain region and compound, with dopamine and serotonin systems playing key roles. These findings provide insight into the neurochemical actions of tryptamine hallucinogens.

DOI: 10.1016/j.neures.2025.04.006 Full text 5-MEO-Amt 5-MEO-Dipt Hplc-ecd Monoaminergic +4

Differential effects of amphetamine and phencyclidine on the expression of growth-associated protein GAP-43.

Neuroscience research June 1, 2001 S Vukosavic, S Ruzdijic, R Veskov et al.

Chronic treatment with amphetamine reduced GAP-43 mRNA expression in rats, an effect that persisted for up to 14 days after the last dose, suggesting a neurotoxic effect. In contrast, phencyclidine increased GAP-43 mRNA expression, detectable from early treatment until 21 days after the last dose, indicating activation of pathways involved in remodeling. Haloperidol did not significantly change GAP-43 mRNA expression.

DOI: 10.1016/s0168-0102(01)00222-x Full text