Neuroticism is associated with challenging experiences with psilocybin mushrooms.
Personality and individual differences October 15, 2017 Frederick S Barrett, Matthew W Johnson, Roland R Griffiths 98 citations
People who score higher on neuroticism (or lower on emotional stability) tend to report more intense challenging experiences, such as fear, grief, and paranoia, during psilocybin sessions. Data from two online surveys with 1,993 and 981 participants showed that scores on the Challenging Experience Questionnaire were negatively associated with emotional stability in the first study and positively associated with neuroticism in the second. The findings suggest that personality traits, particularly neuroticism, may help explain why some individuals have more difficult “bad trips” with classic hallucinogens like psilocybin.