This work profiles the neurochemical binding of novel indole and benzofuran analogues of MDMA at monoamine transporters. The compounds were tested for affinity at serotonin, dopamine, and norepinephrine transporters. Several analogues showed high affinity for the serotonin transporter, with some also binding to dopamine and norepinephrine transporters. The findings suggest these compounds may have psychoactive effects similar to MDMA, but with varying selectivity profiles that could influence their pharmacological and therapeutic potential.
Esketamine, a drug used for treatment-resistant depression, is associated with a range of adverse drug events, including psychiatric, neurological, and cardiovascular effects. Analysis of reports from the US Food and Drug Administration Adverse Event Reporting System identified the most common adverse events as dissociation, sedation, and increased blood pressure. Network toxicology analysis suggested that esketamine may interact with multiple biological targets and pathways, potentially explaining its toxicological mechanisms. The findings indicate that while esketamine is effective, careful monitoring for specific adverse events is warranted.