300 Psilocybin-induced changes in neural reactivity to alcohol and emotional cues in patients with alcohol use disorder: An fMRI pilot study
Journal of Clinical and Translational Science April 1, 2024 Broc A. Pagni, Petros Petridis, Samantha K. Podrebarac et al. 1 citation
In a small pilot study, psilocybin, compared to diphenhydramine, altered brain activity in people with alcohol use disorder when they viewed alcohol and emotional images. Psilocybin increased activity in the medial and lateral prefrontal cortex and left caudate, and decreased activity in the insular, motor, temporal, parietal, and occipital cortices and cerebellum. For negative cues, psilocybin increased supramarginal gyrus activity; for positive cues, it increased right hippocampus activity and decreased left hippocampus activity. These changes suggest enhanced goal-directed action, improved emotional regulation, and diminished craving, warranting larger studies.