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The FASEB Journal

ISSN 0892-6638

27 papers in the library · 156 citations · publishing 1997-2025

Papers

Current Drug Scheduling Reviews Reported by DEA

The FASEB Journal April 1, 2009 Sandy Ghozland, Srihari R. Tella, Michelle D. Walker et al.

The DEA collects and reviews scientific, medical, and other data on substances with abuse potential to determine whether they should be placed under the Controlled Substances Act (CSA). Ongoing scheduling processes involve indiplon, carisoprodol, dextromethorphan, salvinorin A, and several petitions regarding nabilone, methylphenidate, marijuana and tetrahydrocannabinols, tramadol, anabolic steroids, and sibutramine. Many hallucinogens, including 5-MeO-DMT, 5-MeO-AMT, 5-MeO-DET, 5-MeO-MIPT, DIPT, 4-OH-DIPT, 2C-I, 2C-T-2, and Bromo-dragonfly, are under review for possible control. Chemical and pharmacological studies for DOC, 2C-C, 2C-D, and 2C-E are ongoing. Additionally, to comply with the 1971 Convention on Psychotropic Substances, DEA is reviewing zipeprol, amineptine, mesocarb, 4-MTA, and brotizolam for control under the CSA.

DOI: 10.1096/fasebj.23.1_supplement.588.1 Drug control Hallucinogen Pharmacology Controlled substance +2

Discriminative stimulus effects of hallucinogens and psychostimulants in S(+)‐MDMA, and R(−)‐MDMA trained mice

The FASEB Journal March 1, 2008 Kevin Sean Murnane, Leonard L Howell, William E Fantegrossi

MDMA has both stimulant and hallucinogen-like effects, and its two isomers, R(−)-MDMA and S(+)-MDMA, produce different behavioral effects: R(−)-MDMA is hallucinogen-like, while S(+)-MDMA is stimulant-like. In this study, mice were trained to discriminate each isomer from a vehicle in a two-lever operant task. Drugs with hallucinogen-like effects (2C-T-7, DPT) and stimulant-like effects (amphetamine, cocaine) were substituted for the training isomer. Results showed efficacy differences within chemical classes and potency differences within behavioral classes, clarifying the complex discriminative stimulus properties of MDMA isomers.

DOI: 10.1096/fasebj.22.1_supplement.713.2