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Brazilian Journal of Science

ISSN 2764-3417

2 papers in the library · 3 citations · publishing 2024-2025

Papers

Phytochemical screening, phenolic and flavonoid contents, psilocybin, antioxidant, and acetylcholinesterase inhibition activities of the aqueous extract from the fungi Cyathus striatus, Laternea dringii, and Marasmius haematocephalus

Brazilian Journal of Science November 1, 2024 D Silva, Antônio Carlos Pereira de Menezes Filho, Aurélio Ferreira Melo et al. 3 citations

Aqueous extracts from the mushrooms Cyathus striatus, Laternea dringii, and Marasmius haematocephalus contain flavonoids, phenolics, alkaloids, and other phytochemicals. Phenolic content ranged from 100.09 to 208.44 mg GAE g⁻¹, flavonoid content from 39.71 to 56.06 mg QE g⁻¹. Antioxidant activity measured by FRAP ranged from 4.15 to 14.43 µM TE g⁻¹, and by DPPH from 88.12 to 133.65 µg mL⁻¹. Acetylcholinesterase inhibition varied from low to strong: 43.11%, 68.53%, and 77.14% for C. striatus, L. dringii, and M. haematocephalus respectively. These findings suggest the mushrooms harbor bioactive compounds with potential for antioxidant and neuroprotective applications.

Ethical challenges in the therapeutic application of classical psychedelics for pediatric health conditions: A comprehensive review

Brazilian Journal of Science September 29, 2025 Pinelopi Vlotinou, Konstantinos Christodoulou, Anna Tsiakiri et al.

Classical psychedelics like psilocybin, LSD, DMT, and mescaline act on serotonin receptors, altering perception, cognition, and emotion, and can induce lasting neural plasticity. Clinical trials in adults show promise for treating psychiatric disorders, sparking interest in pediatric applications. This review evaluates ethical considerations—autonomy, beneficence, non-maleficence, and justice—for using these compounds in children. While evidence suggests potential benefits, current research is preliminary, with uncertain outcomes and significant limitations, highlighting ethical and practical challenges for this vulnerable population.