Can the gut-brain axis provide insight into psilocybin's therapeutic value in reducing stress?
Neurobiology of Stress May 1, 2025 Alanna Kit, Kate Conway, Savannah Makarowski et al. 5 citations
Psilocybin shows therapeutic potential for stress-related neuropsychiatric disorders like depression, anxiety, PTSD, OCD, addiction, and eating disorders, but its mechanisms are complex, involving multiple body systems. This review explores how psilocybin interacts with the gut microbiota, enteric nervous system, and hypothalamic-pituitary axis, influencing bidirectional communication between peripheral and neuronal systems. Understanding these gut-brain interactions could advance psilocybin-based therapies from preparation through long-term integration, potentially extending benefits beyond psychiatric disorders to inflammatory-related conditions.