Journal of Neuroscience Research

ISSN 0360-4012

2 papers in the library · 47 citations · publishing 2009-2026

Papers

Enzymatic–nonenzymatic cellular antioxidant defense systems response and immunohistochemical detection of MDMA, VMAT2, HSP70, and apoptosis as biomarkers for MDMA (Ecstasy) neurotoxicity

Journal of Neuroscience Research October 1, 2009 Irene Riezzo, Daniela Cerretani, Carmela Fiore et al. 47 citations

A single dose of MDMA (20 mg/kg) in rats rapidly disrupts the brain's antioxidant defenses within hours. Reduced and oxidized glutathione ratios decreased, and antioxidant enzyme activities fell significantly after 3 and 6 hours in the frontal cortex. Ascorbic acid levels rose sharply in the striatum, hippocampus, and frontal cortex after 3 and 6 hours. Malonaldehyde, a marker of oxidative damage, increased in the striatum after 3 and 6 hours and in the hippocampus and frontal cortex after 6 hours. Immunohistochemistry revealed strong antivesicular monoamine transporter 2 positivity in frontal sections, basal ganglia, and thalamus, and heat shock protein 70 appeared in the superficial cortical layer after 24 hours, indicating early neurotoxic changes.

DOI: 10.1002/jnr.22245 MDMA Ecstasy Neurotoxicity Striatum +7

The Effect of Magic Mushroom ( Psilocybe azurescens ) on Social Interaction, Anxiety‐ and Depressive‐Like Behaviors in Male Rats; the Role of Neuroinflammation, Oxidative Stress, and Neurotrophic Factors

Journal of Neuroscience Research January 1, 2026 Hediye Moghadam, Parisa Akbari, Elmira Beirami et al.

Oral consumption of the psilocybin-containing mushroom Psilocybe azurescens at doses of 10, 100, and 250 mg/kg every other day for 14 days increased anxiety- and depressive-like behaviors and disrupted social interaction in male Wistar rats. These behavioral changes were accompanied by elevated neuroinflammation (IL-6 and TNFα) and oxidative stress (ROS and SOD) and reduced neurotrophic factors (BDNF and GDNF) in the hippocampus, prefrontal cortex, and amygdala. The findings suggest that high doses of P. azurescens can induce mood disorders through increased inflammatory responses and oxidative stress alongside decreased neurotrophic factor expression.

DOI: 10.1002/jnr.70107 Psilocybin Oxidative stress Neurotrophic factors Brain-derived neurotrophic factor +12