Journal of Neuroscience Research
October 1, 2009
Irene Riezzo, Daniela Cerretani, Carmela Fiore et al.
47 citations
A single dose of MDMA (20 mg/kg) in rats rapidly disrupts the brain's antioxidant defenses within hours. Reduced and oxidized glutathione ratios decreased, and antioxidant enzyme activities fell significantly after 3 and 6 hours in the frontal cortex. Ascorbic acid levels rose sharply in the striatum, hippocampus, and frontal cortex after 3 and 6 hours. Malonaldehyde, a marker of oxidative damage, increased in the striatum after 3 and 6 hours and in the hippocampus and frontal cortex after 6 hours. Immunohistochemistry revealed strong antivesicular monoamine transporter 2 positivity in frontal sections, basal ganglia, and thalamus, and heat shock protein 70 appeared in the superficial cortical layer after 24 hours, indicating early neurotoxic changes.
Journal of Neuroscience Research
March 3, 2023
Veronika Langová, Petra Horká, Jan Hubený et al.
10 citations
Ketamine, an NMDA receptor antagonist, disrupted electric signaling and navigation in the weakly electric fish Gnathonemus petersii, a candidate model for schizophrenia. Lower doses increased locomotion and erratic movement, while higher doses reduced electric organ discharges, indicating positive schizophrenia-like symptoms. A low dose of haloperidol did not normalize these symptoms, suggesting further testing with more antipsychotic doses is needed to confirm the model's predictive validity.
Journal of Neuroscience Research
January 1, 2026
Hediye Moghadam, Parisa Akbari, Elmira Beirami et al.
Oral consumption of the psilocybin-containing mushroom Psilocybe azurescens at doses of 10, 100, and 250 mg/kg every other day for 14 days increased anxiety- and depressive-like behaviors and disrupted social interaction in male Wistar rats. These behavioral changes were accompanied by elevated neuroinflammation (IL-6 and TNFα) and oxidative stress (ROS and SOD) and reduced neurotrophic factors (BDNF and GDNF) in the hippocampus, prefrontal cortex, and amygdala. The findings suggest that high doses of P. azurescens can induce mood disorders through increased inflammatory responses and oxidative stress alongside decreased neurotrophic factor expression.