Psilocybin in the treatment of eating disorders: a systematic review of the literature and registered clinical trials
Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity July 29, 2025 Francesco Bevione, Maria Carla Lacidogna, Raffaele Lavalle et al. 3 citations
A systematic review of psilocybin for eating disorders found only two original studies meeting inclusion criteria: an open-label feasibility study with 10 individuals with anorexia nervosa and a single case report. Six registered clinical trials were also identified. The initial evidence suggests psilocybin may be safe and well-tolerated in anorexia nervosa, but the authors emphasize the need for larger samples. The review highlights the lack of approved pharmacological treatments for eating disorders beyond fluoxetine for bulimia nervosa and calls for further research.