A floating, controlled-release oral tablet of ketamine hydrochloride was produced using dual-extrusion 3D printing. The tablet shell was fabricated by hot-melt extrusion at 150–160 °C, while the drug-containing gel was extruded at room temperature inside the shell. The optimized tablet achieved total drug release over 12 hours, met United States Pharmacopeia standards for weight variation and content uniformity, and showed no chemical interference or change in drug crystallinity. The method enables patient-tailored dosing with tunable release kinetics, offering a promising approach for managing refractory depression and chronic pain in a point-of-care setting.
A thermosensitive mucoadhesive hydrogel for nasal delivery of the psychedelic drug 5-methoxy-N,N-dimethyltryptamine was developed using a mixture of Poloxamer 407, Poloxamer 188, and Hydroxypropyl-methylcellulose. A Box-Behnken experimental design optimized gelification temperature, viscosity, and mucoadhesion to increase contact time with nasal mucosa while preserving ciliary function. The final formulation gels at around 32 °C, has a viscosity near 100 mPas, and mucoadhesion of about 4.20 N·m. In vitro testing showed sustained release, with 73.76% of the drug delivered after 5 hours. Raman spectroscopy confirmed homogeneous mixing of drug and polymers. The formulation may enable future studies for treating certain mental disorders.