ISSN 0040-3709
2 papers in the library · 70 citations · publishing 1972-1981
Teratology August 1, 1972 Sally Y. Long 51 citations
A review of the literature on LSD (lysergic acid diethylamide) finds that there are reports of five children with limb defects among 161 children born to parents who took the drug, but the evidence does not support that LSD causes chromosome breakage. There is also no strong evidence of teratogenicity in animals.
Teratology June 1, 1981 Kenneth S. Hirsch, Hans Fritz 19 citations
Oral mescaline given to pregnant hamsters on days 7–10 of gestation at 16 or 32 mg/kg reduced reproductive success and delayed skeletal development in a dose-dependent way. At 32 mg/kg, 48.8% of embryos were resorbed, compared to 12.0% at 16 mg/kg and 6.4% in controls. Litter size fell from 12.0 pups in controls to 10.3 at 16 mg/kg and 6.5 at 32 mg/kg. No gross abnormalities were seen, but ossification of the skull, sternum, and metatarsals was increasingly delayed. Epinephrine and norepinephrine at 500 μg/kg also reduced reproductive success; epinephrine increased preimplantation loss, while norepinephrine raised resorptions to 29.1%. Both catecholamines caused similar ossification delays.