Immunological Consequences of In Vitro Exposure to Lysergic Acid Diethylamide (LSD)
Immunopharmacology and Immunotoxicology January 1, 1994 Robert V. House, Peter Thomas, Hemendra N. Bhargava 45 citations
Lysergic acid diethylamide (LSD) directly alters immune function when immune cells are exposed to it in a laboratory setting. At a high concentration of 100 microM, LSD suppresses the proliferation of B-lymphocytes, reduces production of the cytokines IL-2, IL-4, and IL-6, and inhibits the induction of cytotoxic T-lymphocytes. In contrast, at lower concentrations between 0.0001 and 0.1 microM, LSD enhances both basal and IL-2-augmented natural killer (NK) cell activity. These differential effects suggest that LSD can directly influence components of the immune system at concentrations potentially reached in the human body.