HIV is now a chronic illness, making it urgent to address social factors affecting health outcomes. A review of studies from the last decade on mental health interventions for sexual and gender minority older adults living with HIV found only two studies for inclusion. The review identifies several emerging intervention models tailored to this group: age-sensitive and culturally adapted therapies, mindfulness and meditation-based stress reduction, group therapy, digital mental health resources, and psilocybin-assisted group therapy. These approaches aim to meet the unique needs of this population.
Posttraumatic Stress Disorder (PTSD) and Alcohol Use Disorder (AUD) frequently co-occur, leading to worse outcomes and higher relapse rates. Ketamine can produce rapid and lasting reductions in PTSD symptoms and AUD relapse. Prazosin effectively treats PTSD-related nightmares and may lower alcohol consumption in people with high autonomic reactivity. Because these drugs work through complementary mechanisms—modulating glutamatergic transmission and reducing noradrenergic hyperactivity—combining them may improve stabilization, readiness for trauma-focused therapy, and broader symptom control. Although this combination has not been tested in clinical trials, it warrants nurse practitioner-led research to evaluate safety, efficacy, and integration into multidisciplinary care.