Carvedilol reverses hyperthermia and attenuates rhabdomyolysis induced by 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) in an animal model*
Critical Care Medicine June 1, 2005 Jon E. Sprague, Petra Moze, David Caden et al. 75 citations
MDMA (ecstasy) can cause dangerously high body temperature (hyperthermia). New evidence suggests that alpha1 and beta3-adrenergic receptors play a role in this effect. The drug carvedilol, which blocks these receptors, may be a promising candidate for treating psychostimulant-induced hyperthermia and its complications, such as rhabdomyolysis. Further research into such therapies is warranted.