Cardiac effects of MDMA on the metabolic profile determined with 1H‐magnetic resonance spectroscopy in the rat
NMR in Biomedicine November 4, 2008 Shane A. Perrine, Mark S. Michaels, Farhad Ghoddoussi et al. 39 citations
MDMA (ecstasy) dose-dependently increased body temperature and decreased serotonin levels in heart tissue of rats. The drug altered cardiac metabolites, increasing carnitine while decreasing choline, with no change in other energy-related compounds. These effects suggest MDMA disrupts energy regulation in heart tissue, potentially shifting metabolism toward fatty acid use, and affects cardiovascular serotonergic signaling.