Age-dependent (+)MDMA-mediated Neurotoxicity in Mice
NeuroToxicology July 6, 2005 María E. Reverón, Terrence J. Monks, Christine L. Duvauchelle 24 citations
Older mice (10-week-old) given a neurotoxic regimen of MDMA showed greater hyperthermia and more severe dopaminergic damage than younger mice (4-week-old). Seven days after treatment, older animals had significant reductions in vesicular monoamine transporter 2 (37%) and tyrosine hydroxylase (58%), while younger animals did not. Dopamine transporter expression dropped in both age groups (26% in younger, 69.7% in older), and striatal dopamine and its metabolite were lower in both, with older animals more affected. The findings indicate age-related susceptibility to MDMA-induced neurotoxicity.