Palladium-Catalyzed Alkylation-Alkenylation Reactions: Rapid Access to Tricyclic Mescaline Analogues
Synlett October 25, 2006 Mark Lautens, Dino Alberico 10 citations
A one-pot catalytic sequence uses palladium and norbornene to form two alkyl-aryl bonds and one alkenyl-aryl bond simultaneously. Starting from a Heck acceptor and an aryl iodide with two attached alkyl bromides, the method produces a range of symmetrical and unsymmetrical tricyclic heterocycles in good yields. The approach was demonstrated by synthesizing a tricyclic analogue of mescaline.