Understanding brain states across spacetime informed by whole-brain modelling
Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences May 23, 2022 Jakub Vohryzek, Joana Cabral, Peter Vuust et al. 62 citations
The brain balances order and disorder in its activity patterns to adapt to a complex environment. Depression involves excessively rigid, ordered brain states, while psychedelics induce more disordered, overly flexible states. This review uses dynamical system theory and neuroimaging to characterize how different healthy and altered brain states correspond to distinct spacetime dynamics, potentially guiding new treatments for rebalancing brain states in disease.