Neuroprotective Effect of Jobelyn® on Ketamine-Induced Schizophrenia-Like Behaviors and Oxidative Damage in Mice Brain
Pharmacology and Toxicology of Natural Medicines July 7, 2026 Itivere Adrian Omogbiya, Benneth Ben‐azu, Maxwell Oboh et al.
A commercial polyherbal formulation, Jobelyn (JB), prevented and reversed schizophrenia-like behaviors and oxidative damage in mice given ketamine. Ketamine increased locomotion and impaired memory, while reducing antioxidant enzymes superoxide dismutase, catalase, and glutathione, and increasing lipid peroxidation. JB (5, 10, or 50 mg/kg) and the antipsychotic risperidone significantly blocked these behavioral changes and restored antioxidant levels. The findings suggest JB acts through a neuroprotective antioxidant mechanism and may be a candidate for further evaluation as an antipsychotic agent.