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Zhonghua xingwei yixue yu naokexue zazhi

ISSN 1674-6554

2 papers in the library · publishing 2012-2017

Papers

Effects of short term low dose melatonin and ketamine on depressive behavior and BDNF expression in rats with chronic stress depression

Zhonghua xingwei yixue yu naokexue zazhi December 20, 2017 Haonan Li, Hongwei Sun, Yanyu Wang et al.

In a rat model of depression induced by chronic unpredictable mild stress, melatonin produced antidepressant-like effects comparable to those of ketamine. Rats exposed to 42 days of stress showed depressive-like behavior, indicated by reduced sucrose preference and increased immobility time in the forced swim test. After 14 days of treatment, both melatonin and ketamine significantly decreased immobility time and increased the number of BDNF-positive cells in the prefrontal cortex compared to stressed controls. Melatonin also increased BDNF cell counts more than ketamine did. However, only ketamine, not melatonin, significantly raised GluR1 cell counts. These findings suggest melatonin's antidepressant action may involve upregulation of BDNF.

DOI: 10.3760/cma.j.issn.1674-6554.2017.12.003 Behavioural despair test Melatonin Internal medicine Chronic stress +7

Role of L-arginine/nitric oxide pathway in the antidepressant effects of ketamine

Zhonghua xingwei yixue yu naokexue zazhi September 20, 2012 Guang-Fen Zhang, Nan Wang, Jinyun Shi et al.

In rats subjected to the forced swimming test, ketamine at 10 mg/kg reduced immobility time, an indicator of antidepressant-like effect, and lowered hippocampal nitric oxide (NO) levels. The NO precursor L-arginine increased NO and blocked ketamine's behavioral effect, while the NO synthase inhibitor L-NAME enhanced the effect of a low ketamine dose (3 mg/kg) and also reduced NO. These findings suggest that ketamine's antidepressant action involves suppression of the L-arginine/nitric oxide pathway.

DOI: 10.3760/cma.j.issn.1674-6554.2012.09.008 Ketamine Behavioural despair test Saline Nitric oxide synthase +8