Association of Patient Characteristics With Recovery in Adults With Disorders of Consciousness.
Archives of physical medicine and rehabilitation April 24, 2025 Alison M Cogan, Patricia Grady-Dominguez, Caitlin G Dobson et al.
Among 696 adults with disorders of consciousness after severe brain injury in specialized rehabilitation programs, two-thirds improved beyond measurement error on the Coma Recovery Scale-Revised, while 23 declined and 228 showed no reliable change. Patients who began rehabilitation sooner after injury were more likely to show true improvement. Early change during the first two weeks did not predict change in the following two weeks, indicating that progress is not linear and that precise measurement is needed to guide treatment decisions.