Contemplative practitioners (long-term meditators and yoga practitioners) show higher levels of maturity development—a measure of adult self-development—than matched controls. Maturity development correlates with cortical thickness in the posterior cingulate, a brain region involved in self-referential and narrative processing. The study identifies a brain network including the posterior cingulate cortex, dorsomedial prefrontal cortex, temporoparietal junction, and inferior frontal cortex as a primary neural correlate of maturity development.
Frequent cannabis use, especially daily use, and the consumption of high-potency cannabis are associated with a higher risk of developing psychosis. Several genotypes moderate this impact, particularly those involved in dopamine function, such as AKT1. Cannabis use is also linked to an earlier onset of psychosis and an increased risk of transition in individuals at clinical high risk. Changing cannabis use behavior could be a harm reduction strategy to lower psychosis risk.