Potential Anti-Depressive Treatment Maneuvers from Bench to Bedside
Depressive Disorders: Mechanisms, Measurement and Management January 1, 2019 Min Cai, Huaning Wang, Xia Zhang 4 citations
Many antidepressants exist for major depressive disorder, but their limitations—poor response, delayed onset, and safety concerns—drive the search for new drugs with novel mechanisms and fewer side effects. This chapter reviews compounds showing clinical promise in various phase trials. Though most strategies currently address treatment-resistant depression, some, like ketamine, may become routine. The review covers mechanisms involving glutamatergic, opiate, and cholinergic receptors, as well as neuroplasticity, and includes supplemental approaches such as polyunsaturated fatty acids for their antidepressant properties.