Current Trends in Identifying Rapidly Acting Treatments for Depression.
Current behavioral neuroscience reports June 1, 2016 Dawn F Ionescu, George I Papakostas
Traditional antidepressants take weeks to months to work, but ketamine's rapid effects have spurred a decade and a half of research into treatments that act within hours to days, shifting antidepressant drug development. This review highlights recent trends in identifying rapidly-acting antidepressants, discussing ketamine, GLYX-13, nitrous oxide, metabotropic glutamatergic receptor modulators, scopolamine, opioid-receptor modulators, and low field magnetic stimulation.