Dextromethorphan/bupropion in major depressive disorder: a profile of its use
Drugs & therapy perspectives July 6, 2023 Hannah A. Blair
A fixed-dose combination of dextromethorphan and bupropion (AUVELITY) is an effective and generally well-tolerated treatment for adults with major depressive disorder. In randomized, double-blind clinical trials, it produced early, clinically meaningful improvements in depressive symptoms, remission rates, and functional disability compared with placebo or bupropion alone, with benefits sustained over the longer term. The combination was not associated with increased psychotomimetic effects, weight gain, or suicidal behaviors; common adverse events were dizziness and nausea.