Ketamine is a non-inferior treatment option to electroconvulsive therapy (ECT) for major depressive disorder, with potential advantages in memory function. A meta-analysis of six randomized controlled trials involving 643 patients found no significant difference between ketamine and ECT in reducing depression symptom severity or in response rates. However, ketamine was associated with superior memory function improvement compared to ECT. Ketamine also led to higher rates of dissociative symptoms, blurred vision, and dizziness, but a lower incidence of muscle pain. The limited number of studies highlights the need for further large-scale randomized controlled trials to confirm these findings.
Entrapment—a feeling of being trapped—harms the mental well-being of married individuals, and mindfulness within the marriage plays a mediating role. Data from 423 married couples (846 people) showed that for both husbands and wives, one partner's entrapment predicted the other partner's mindfulness, which in turn predicted the first partner's mental well-being. For example, women's entrapment predicted their own well-being through men's mindfulness, and women's mindfulness predicted men's well-being. Higher mindfulness in a spouse experiencing entrapment is expected to improve both partners' well-being.