Seizures, Systemic Inflammatory Response, and Rhabdomyolysis Associated With Laboratory-Confirmed 2C-I and 25-I Exposure.
Pediatric emergency care October 1, 2018 Stephen L Thornton, Sarah Hoehn, Roy R Gerona 6 citations
A 17-year-old male experienced seizures, systemic inflammatory response, and rhabdomyolysis after taking what he thought was LSD, but laboratory testing confirmed exposure to the designer drugs 4-iodo-2,5-dimethoxyphenethylamine (2C-I) and its n-benzyloxymethyl analog (25I-NBOMe). Seizures resolved with midazolam, but he required intubation. His urine drug screen was negative. Creatine kinase peaked at 14,579 U/L, and creatinine at 2.46 mg/dL. He recovered fully with intravenous fluids and was discharged after five days. The 2C drugs and their analogs are potent serotonergic agents associated with severe toxicity including seizures, rhabdomyolysis, and death, and should be considered in cases of drug-induced seizures.