Medullary serotonergic neurons are insensitive to 5-MeoDMT and LSD.
J Heym, G F Steinfels, B L Jacobs
European journal of pharmacology July 30, 1982 DOI: 10.1016/0014-2999(82)90360-0 via PubMed
Summary
AI-generated from the abstractIn freely moving cats, neurons in the dorsal raphe nucleus (DRN) are much more sensitive to the psychedelic compounds 5-MeO-DMT and LSD than neurons in the nucleus raphe pallidus (NRP). Low, behaviorally effective doses of these drugs strongly suppress activity in DRN neurons, while NRP neurons remain largely unaffected. This differential sensitivity suggests a unique autoregulatory control mechanism within distinct brain regions, where serotonin-producing neurons respond differently depending on their neuroanatomical location.
Study at a glance
| Characteristics | Comparative study Peer reviewed |
|---|---|
| Population | Freely moving cats |
| Intervention | LSD |
| Dose | low doses |
| Topics | LSD |
| Keywords | Psychedelics 5-meodmt Psychedelic compounds Psychoactive drugs |
| Citations | 21 |
| Key finding | Neurons in the dorsal raphe nucleus are substantially more responsive to 5-MeO-DMT and LSD than neurons in the nucleus raphe pallidus, with low doses strongly suppressing DRN activity while NRP neurons are largely unaffected. |
Abstract
A comparison was made of the effects of 5-MeoDMT or LSD on serotonergic unit activity in the dorsal raphe nucleus (DRN) and nucleus raphe pallidus (NRP) of freely moving cats. NRP neurons were substantially less responsive than DRN neurons to both drugs. NRP neurons were unresponsive to behaviorally effective low doses of these drugs whereas the activity of DRN neurons was strongly depressed. These data are discussed in terms of autoregulatory control of serotonergic neurons.