2,5-Dimethoxy-4-methyl-amphetamine (STP): A New Hallucinogenic Drug
Solomon H. Snyder, Louis A. Faillace, Leo E. Hollister
Science November 3, 1967 DOI: 10.1126/science.158.3801.669 via OpenAlex
Summary
AI-generated from the abstractIn two independent trials with normal volunteers, 2,5-dimethoxy-4-methyl-amphetamine (the active chemical in the hallucinogenic drug STP) produced mild euphoria at low doses. Doses above 3 milligrams caused pronounced hallucinogenic effects lasting about 8 hours, similar to those from hallucinogenic doses of lysergic acid diethylamide, mescaline, and psilocybin. The compound is chemically related to both mescaline and amphetamine, about 100 times more potent as a hallucinogen than mescaline, and only one-thirtieth as potent as lysergic acid diethylamide. Chlorpromazine did not accentuate its psychological effects.
Study at a glance
| Characteristics | Observational study Peer reviewed |
|---|---|
| Population | Normal control volunteers |
| Interventions | 2 5-Dimethoxy-4-methyl-amphetamine |
| Dose | greater than 3 milligrams |
| Duration | About 8 hours |
| Topics | LSD Mescaline Psilocybin |
| Keywords | Hallucinogen Euphoriant |
| Citations | 146 |
| Key finding | 2,5-Dimethoxy-4-methyl-amphetamine produces mild euphoria at low doses and pronounced hallucinogenic effects at doses above 3 milligrams, with potency between mescaline and lysergic acid diethylamide. |
Abstract
We have assessed the effects in normal control volunteers of 2,5-dimethoxy-4-methyl-amphetamine, the chemical present in the hallucinogenic drug STP, in two independent trials. In low doses, this compound produces a mild euphoria. Doses greater than 3 milligrams may cause pronounced hallucinogenic effects lasting about 8 hours and similar to those produced by hallucinogenic doses of lysergic acid diethylamide, mescaline, and psilocybin. 2,5-Dimethoxy-4-methyl-amphetamine, which is chemically related to mescaline and amphetamine, is about 100 times more potent as a hallucinogen than mescaline and only one-thirtieth as potent as lysergic acid diethylamide. Its psychological effects are not accentuated by chlorpromazine.